5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting
نویسندگان
چکیده
منابع مشابه
5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting
Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene silencing. Intended strand selection will increase potency and reduce off-target effects from the unintended strand. Sometimes, blocking RISC loa...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2013
ISSN: 2162-2531
DOI: 10.1038/mtna.2013.36